Las plantas como fuente de compuestos fotoprotectores frente al daño en el ADN producido por la radiación ultravioleta

  • Jorge Luis Fuentes Lorenzo Laboratorio de Microbiología y Mutagénesis Ambiental, Grupo de Investigación en Microbiología y Genética, Escuela de Biología, Facultad de Ciencias; Centro de Investigación en Biomoléculas, CIBIMOL, Universidad Industrial de Santander, Bucaramanga, Colombia http://orcid.org/0000-0001-8112-0554
Palabras clave: Radiación ultravioleta; Fotoprotección; Antigenotoxicidad; Metabolitos secundiarios de plantas, Ultraviolet radiation; Photoprotection; Antigenotoxicity; Plant secondary metabolites.

Resumen

La fotoprotección es una estrategia preventiva y terapéutica frente al cáncer y el envejecimiento de la piel. En el presente trabajo se revisan los efectos biológicos adversos de la radiación ultravioleta, los conceptos básicos relevantes de la fotoprotección y los métodos para llevar a cabo su medición. Asimismo, se resumen los resultados obtenidos de la caracterización radiobiológica y genética del modelo experimental (SOS Chromotest) usado para la bioprospección de extractos y moléculas de origen vegetal con potencial en fotoprotección. Además, se presentan datos sobre la eficacia fotoprotectora y las estimaciones del efecto antigenotóxico de aceites esenciales y extractos obtenidos de especies de plantas, así como de los compuestos mayoritarios de los aceites y extractos promisorios analizados en este estudio. Por último, se postulan posibles mecanismos de acción de algunas moléculas relevantes. Los resultados se presentan y discuten destacando su potencial uso para el desarrollo de bloqueadores solares multifuncionales.

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Publicado
2019-09-25
Cómo citar
Fuentes Lorenzo, J. L. (2019). Las plantas como fuente de compuestos fotoprotectores frente al daño en el ADN producido por la radiación ultravioleta. Revista De La Academia Colombiana De Ciencias Exactas, Físicas Y Naturales, 43(168), 550-562. https://doi.org/10.18257/raccefyn.841
Sección
Ciencias de la tierra