DOI: http://dx.doi.org/10.18257/raccefyn.542

Artículo de posesión

La fitoterapia como fuente de medicamentos reguladores del metabolismo tumoral y activadores de la respuesta inmunitaria

Susana Fiorentino, Claudia Urueña

Resumen


El término cáncer integra un grupo de enfermedades complejas que responden a múltiples factores y se manifiestan de forma diferente según el órgano afectado o el mecanismo molecular implicado. En términos generales, se presenta una alteración en los mecanismos que regulan el crecimiento de las células, lo cual genera proliferaciones incontroladas que rompen la homeóstasis normal del organismo y afectando no solo el órgano blanco sino a todo el organismo. La búsqueda de terapias contra el cáncer se basa en el conocimiento de estos mecanismos moleculares y sus innumerables consecuencias. En esta revisión se recogen los estudios realizados y publicados por nuestro grupo de investigación en los últimos 13 años en torno a Caesalpinia spinosa (Molina) Kuntze y Petiveria alliacea Linne (Phytolaccaceae), así como algunos datos aún no publicados. La revisión se centra en los mecanismos relacionados con el metabolismo energético tumoral y la regulación de la respuesta inmunitaria, así como en los últimos procedimientos requeridos para llevar a cabo el primer ensayo clínico de fase I para un medicamento contra el cáncer en Colombia. © 2018. Acad. Colomb. Cienc. Ex. Fis. Nat.


Palabras clave


Cáncer; Fitomedicamentos; Metabolismo tumoral; Respuesta inmune antitumoral; Anamú; Dividivi.

Texto completo:

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Referencias


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