DOI: http://dx.doi.org/10.18257/raccefyn.506

Artículo de posesión

La respuesta inmunitaria adaptativa en la infección crónica por Trypanosoma cruzi

John M. Gonzalez, Adriana Cuéllar, Concepción J. Puerta

Resumen


La infección por Trypanosoma cruzi causa la enfermedad de Chagas, la cual presenta una fase aguda en la que la activación del sistema inmunitario ayuda a controlar el parásito. No obstante, el parásito puede persistir en bajos niveles y producir una fase crónica en la cual el 70 % de los individuos infectados permanece asintomático, en tanto que los demás presentan compromiso tisular, principalmente en el corazón, y pueden desarrollar una miocardiopatía inflamatoria crónica. Durante el proceso de infección la respuesta inmunitaria tiene un papel importante en la protección, pero también se ha asociado con la patogenia, especialmente en la fase crónica. Los estudios del grupo de investigación sobre la enfermedad de Chagas conformado por investigadores de la Universidad de los Andes y la Pontificia Universidad Javeriana en Colombia, se han centrado en analizar la respuesta inmunitaria adaptativa inducida frente a T. cruzi. En este artículo, se resumen y analizan los resultados de la evaluación de la respuesta inmunitaria humoral contra la proteína KMP-11 del parásito, así como de la respuesta inmunitaria celular en sangre periférica de pacientes con cardiopatía chagásica crónica. La funcionalidad de los anticuerpos específicos y el porcentaje de linfocitos T específicos de antígeno en sangre periférica y sus marcadores de funcionalidad se evaluaron usando un péptido de nueve aminoácidos de la proteína KMP-11 denominado TcTLE. © 2017. Acad. Colomb. Cienc. Ex. Fis. Nat.

 


Palabras clave


Enfermedad de Chagas; Trypanosoma cruzi; Linfocitos T; Anticuerpos.

Texto completo:

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Referencias


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