DOI: http://dx.doi.org/10.18257/raccefyn.355

Artículo de posesión

Los diversos efectos de las helmintiasis sobre la inflamación alérgica

Luis Caraballo

Resumen


Las helmintiasis y las alergias son muy frecuentes en países del trópico, donde establecen múltiples interacciones. Los mecanismos de defensa contra estos parásitos son bastante parecidos a la respuesta inmunológica de tipo alérgico, principalmente porque ambos procesos tienen una importante participación de los anticuerpos tipo inmunoglobulina E (IgE). Pero también hay diferencias importantes, siendo una de ellas el grado de inmunomodulación, el cual es débil en la respuesta alérgica y fuerte en la antihelmíntica. Este tema tiene repercusiones en medicina porque algunas helmintiasis como la ascariasis (producida por Ascaris lumbricoides), son capaces de modificar el curso de las enfermedades alérgicas, en ocasiones disminuyendo su intensidad, por lo cual se ha propuesto que una de las razones del incremento de las alergias en el mundo es la disminución progresiva de las infecciones por helmintos. En esta revisión analizaremos varios de los efectos de las helmintiasis sobre la respuesta inmunológica alérgica y especularemos sobre su influencia en las tendencias internacionales de incremento de los problemas inflamatorios de origen inmunológico. © 2016. Acad. Colomb. Cienc. Ex. Fis. Nat. Todos los derechos reservados. 


Palabras clave


Helmintiasi; Inmunomodulación; IgE; Alergia; Epidemiología; Respuesta alérgica.

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Referencias


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