DOI: http://dx.doi.org/10.18257/raccefyn.300

Artículo de revisión

Papel del TGF-β en la inmunidad contra los rotavirus

Manuel Antonio Franco-Cortés

Resumen


La vía de entrada y el principal sitio de replicación de los rotavirus es el intestino delgado. En este órgano el TGF-β juega un papel muy importante para mantener la tolerancia a los alimentos y microorganismos comensales. Por esta razon, es probable que esta citocina juegue un papel modulador en esta infección. Experimentos in vitro de nuestro laboratorio han mostrado que células humanas epiteliales infectadas por rotavirus aumentan la secreción de TGF-β y promueven una baja respuesta de linfocitos T, la que es necesaria para la inmunidad antiviral. En este artículo de revisión se analiza en forma crítica la hipótesis que los rotavirus inducen la producción de TGF-β como mecanismo de evasión inmune. © 2016. Acad. Colomb. Cienc. Ex. Fis. Nat. Todos los derechos reservados.

Palabras clave


Rotavirus; Inmunidad intestinal; Factor de crecimiento transformante beta; Tolerancia inmunológica; Evasión inmunológica de virus.

Texto completo:

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Referencias


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