Heterogeneidad de las células B de memoria IgM humanas

Resumen

El origen, la función y el repertorio de las células B de memoria IgM humanas (caracterizadas por ser positivas para CD27 IgM e IgD) son controvertidos, y se ha propuesto que esta población es heterogénea. Aunque algunas veces contradictorias, las evidencias actuales apuntan a la existencia de por lo menos dos subpoblaciones de dichas células en sangre: por un lado, células B circulantes de la zona marginal del bazo, con algunas características similares a las células innatas y probablemente responsables de las respuestas de activación independiente de los linfocitos T, que protegen contra bacterias encapsuladas como Streptococcus sp, y, por otro lado, células B con indicios de haber pasado por centros germinales que se asemejan a las células B de la respuesta adaptativa, y que serían un reservorio de células B de larga vida a partir del cual se reconstituirían continuamente las células B de memoria conmutadas. Aunque se ha propuesto que la expresión diferencial de IgM e IgD en las células B de memoria IgM serviría para distinguir estas dos subpoblaciones de células B, se requieren más estudios fenotípicos y funcionales para sustentar esta clasificación. © 2016. Acad. Colomb. Cienc. Ex. Fis. Nat. Todos los derechos reservados.

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Publicado
2016-03-28
Cómo citar
Ángel, J. (2016). Heterogeneidad de las células B de memoria IgM humanas. Revista De La Academia Colombiana De Ciencias Exactas, Físicas Y Naturales, 40(154), 8-17. https://doi.org/10.18257/raccefyn.299
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Ciencias biomédicas